This article provides a comprehensive overview of surgical knot tying, emphasizing the importance of suture material selection, sizing, and knot tying techniques. It categorizes sutures by structure, absorbability, and origin, detailing their appropriate clinical uses. The text describes common knots, including the square and surgeon’s knots, and explains two-handed and one-handed knot tying methods with practical tips for secure, reliable knots. Accompanied by a detailed instructional video, this resource supports surgical trainees and practitioners in mastering essential skills for effective wound closure.