This video describes the surgical technique for an open duodenal resection and antrectomy, which was performed for a neuroendocrine tumor of the duodenal bulb. In this procedure, we start with an upper midline laparotomy and proceed with mobilization of the distal stomach, duodenum, and head of the pancreas. To mobilize, we Kocherize the duodenum, then ligate that right gastric artery and dissect the gastrohepatic ligament, followed by ligation of the right gastroepiploic vessels and take down the gastrocolic ligament exposing the lesser sac. Once the structures are adequately mobilized, we dissect the first portion of the duodenum off of the head of the pancreas and transect it with a TA stapler. The antrectomy is performed next, removing the specimen. For the reconstruction, we perform a retrocolic end-to-side hand-sewn gastrojejunostomy. This technique can be used for multiple indications, including peptic ulcer disease and other mass lesions of the antrum, pylorus, or duodenal bulb.