Nasolacrimal duct obstruction (NDO) is the most common disorder of the lacrimal system that affects patients of every age and results in excessive tearing (epiphora) and if untreated, painful infection (dacryocystitis). When NDO symptoms progress and can no longer be managed with conservative measures, endoscopic dacryocystorhinostomy (DCR) is indicated. In this case, DCR exploration of the nasolacrimal anatomy is performed on a cadaver. The typical presentation of NDO is epiphora but the presence of painful swelling of the medial canthus and mucoid or purulent discharge may indicate the presence of dacryocystitis. The approach presented here is similar to the technique described by Tsirbas and Wormald in 2003 and involves the creation of a mucosal flap and subsequent use of the DCR drill to expose the nasolacrimal duct anatomy. Stenting and subsequent marsupialization of the flap is not shown in the cadaveric dissection. Postoperatively, patients are typically advised to use nasal irrigation twice daily with saline for six weeks and complete a 1-week course of PO antibiotics and 5-day course of antimicrobial eye drops.