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  • 1. Endoscopy/Port Placement
  • 2. Lysis of Adhesions and Hiatal Dissection
  • 3. Vagotomy
  • 4. Hiatal Hernia Repair
  • 5. Division of Roux Limb
  • 6. Partial Gastrectomy/Resection of Ulcer
  • 7. Rerouting of Roux Limb
  • 8. New GJ Anastomosis
  • 9. Endoscopy for Testing of Anastomosis
  • 10. Closure
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Laparoscopic Gastric Bypass Revision

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Deborah D. Tsao, BS1; Janey Sue Pratt, MD2
1Medical Student, Stanford University School of Medicine
2Massachusetts General Hospital

Main Text

Gastrogastric fistula is a rare complication following a roux-en-y gastric bypass procedure wherein there is a communication between the proximal gastric pouch and the distal gastric remnant. Patients typically present with nausea and vomiting, abdominal pain, intractable marginal ulcer, bleeding, reflux, poor weight loss, and weight regain. Etiologies include postoperative Roux-en-Y gastric bypass leaks, incomplete gastric division, marginal ulcers, distal obstruction, and erosion of a foreign body. Diagnosis is made through upper gastrointestinal contrast radiography or CT scan and endoscopy. Barium contrast radiography is particularly useful and is the preferred initial study method for the detection of staple-line dehiscence, which may be small and overlooked during endoscopy. Once identified, a gastrogastric fistula may be treated surgically with remnant gastrectomy or gastrojejunostomy revision. Here, we present a case of a female patient status post Roux-en-Y gastric bypass surgery who presented with abdominal pain. Upon endoscopy, she was noted to have an inflamed gastric pouch and a gastogastric fistula. A laparoscopic gastric bypass revision was done to divide the gastrogastric fistula and to separate the gastric pouch from the gastric remnant in order to alleviate the inflamed gastric pouch and prevent further ulcer formation.

Obesity is one of the fastest-growing public health concerns in the United States. Of the currently available management options, it is evident that metabolic and bariatric surgery (MBS) is among the most effective at inducing long-term weight loss and resolution of obesity-related co-morbidities such as type 2 diabetes, obstructive sleep apnea, and non-alcoholic fatty liver disease. The Roux-en-Y gastric bypass (RYGB) remains one of the most effective and durable metabolic and bariatric procedures producing consistently excellent weight loss and metabolic outcomes.12  Although effective, MBS is still a major surgery that carries the risk of various complications. Marginal ulcers (MU) are a relatively common complication that occurs following RYGB. MU typically form at the gastrojejunal anastomosis in the proximal jejunum.3 The reported incidence of marginal ulcers varies widely, typically in a range between 1% to 16% of all RYGB cases.4-6 This variability is likely due to the retrospective nature of many studies, and the inconsistencies in diagnosing MU – some only include those diagnosed by endoscopy, while others include those with a probably clinical history. Furthermore, because endoscopy is typically performed on symptomatic patients only, some studies miss asymptomatic MU cases.7 In a prospective study using endoscopy to screen all RYGB patients at one month following surgery, MU was found in 5.6% of patients.7

Patients with marginal ulcers most commonly present with epigastric pain (50-60%) and/or bleeding (15-25%) which may manifest as melena or hematemesis.38 About 20% of patients also experience nausea and vomiting. If the MU is accompanied by other complications, additional symptoms may appear in history. Gastrogastric fistulas, which occur in approximately 1.18% of patients undergoing RYGB, present with weight regain, insulin resistance, and pain.9 MU perforations may present with pain and an acute abdomen.10 Stenosis, a complication of untreated marginal ulcers, presents with dysphagia, solid food intolerance, and delayed vomiting of undigested food.11 Critically, up to 28% of patients with MU may be asymptomatic, and some patients may present only with painless upper GI bleeding.7 

The patient’s history may also reveal modifiable risk factors for developing MU. Smoking history is one of the strongest independent predictors of MU developing following RYGB, conferring nearly 5-fold higher risk compared to non-smokers regardless of how heavily they smoke or even whether the patient has quit smoking.1213 Similar to regular peptic ulcers, NSAID use also contributes to increased incidence and impaired healing of MU after RYGB, although some studies dispute this.14-16 Daily low-dose aspirin has not been found to increase MU risk.17 Some studies have found a significant association between diabetes and MU incidence, while others have not.318 BMI and alcohol use do not appear to predict MU occurrence.1920

Marginal ulcers are primarily diagnosed by symptoms and imaging, but physicians may note physical exam findings secondary to the primary ulcer. If they have a bleeding ulcer, the patient may be anemic and show pale skin, tachycardia, and postural hypotension. Patients may be malnourished and dehydrated, caused by food avoidance due to pain, chronic vomiting, or gastric stricture. Dehydration may present with ketosis, tachycardia, sunken eyes, and decreased skin turgor, and suspicion of malnutrition warrants blood labs for micronutrients and serum proteins.

Upon presentation with symptoms consistent with a marginal ulcer, patients should undergo imaging for definitive diagnosis. An upper GI series or a CT scan with oral contrast are both rapid and effective methods to detect fistulas following gastric bypass however they are not sensitive for detecting MU.9 If the patient presents with signs of bleeding, a CT scan with IV contrast may also help identify the bleeding source. Upper GI endoscopy is the gold standard for diagnosing MU, enabling providers to note the size of the ulcer and the presence of any removable foreign bodies such as sutures or staples.20 Endoscopy can also offer therapeutic intervention such as bleeding control, dilatation of strictures, or closure of fistulas. In one study of patients who received endoscopy for upper GI symptoms following RYGB, 15.8% were diagnosed with marginal ulceration.21 In the same study, patients who developed symptoms three months or earlier in the postoperative period were more likely to have an abnormal endoscopy result.21

The natural history of marginal ulcers can be divided into the etiologies that cause them, and the potential complications that follow them.  

Etiology: Acid

Similar to regular peptic ulcers, acid is also related to the pathogenesis of marginal ulcers. Current surgical standards for RYGB creates a small, proximal pouch that excludes most of the parietal cells in the antrum, significantly reducing the risk of developing MU.8 In cases of dilated pouches or gastrogastric fistulas, the pouch or the gastric remnant may produce excessive acid that is passed to the jejunum, which lacks the buffering capacity of the duodenum. These patients are at high risk of developing marginal ulcers. Although it is clear that acid impairs ulcer healing, it cannot explain the etiology of all marginal ulcers because patients still form ulcers early in their recovery course when pouches are not yet dilated, and some marginal ulcers don’t heal even with high-dose proton-pump inhibitors (PPI).15 

Etiology: Ischemia

Local ischemia significantly increases the risk of marginal ulceration.8 Smoking, diabetes, and coronary artery disease all cause microvascular insufficiency and ischemia and are all independent risk factors for developing MU.315 Furthermore, the blood supply in the mesentery is often disrupted during surgery, and the resultant anatomy requires that blood must flow anti-gravity to reach the gastrojejunostomy. The anastomosis, most distal to the blood supply, is most likely to contain an ischemic ulcer.3 Furthermore, ulcers biopsied and excised routinely show ischemic pathology. 

Etiology: Foreign body

During diagnostic endoscopy, sutures or staples are found in approximately one-third of marginal ulcers.18 The foreign body causes irritation and mucosal erosion, significantly increasing ulcer risk. For this reason, many surgeons now opt for absorbable sutures, which significantly reduces the risk of MU and gastrogastric fistula development.22 

Etiology: H. Pylori

The exact role of H. pylori in the pathogenesis of MU is unclear. Some studies have not found an increased complication rate in patients infected with H. pylori, while others have identified H. pylori infection as an independent predictor of MU formation following gastric bypass.2324 Compared to peptic ulcers in the general population, H. pylori is not an important risk factor for marginal ulcers, although many bariatric centers still screen for H. pylori and pre-operative H. pylori eradication is widely practiced.2526 

Complication: Fistula

One study found that nearly one-fifth of patients diagnosed with MU also had a concomitant gastrogastric fistula (GGF). GGFs are much more common in patients who have undergone gastric partitioning used in open surgery instead of the divided gastric pouch created in laparoscopic and robotic surgeries; however, the incidence of MU is no different.27 In some cases the fistula may be a result of a prior leak or staple line disruption that occurs in the pouch and is not directly associated with the ulcer. In other cases, the ulcer creates the fistula by eroding into the gastric remnant or adjacent organs. Of patients with GGF, 60% have a history of marginal ulcers.9 Although gastrogastric fistulas are most common, fistulas related to MU can also involve the small intestine, colon, pancreas, liver, and major blood vessels including in one reported case, the aorta.28 

Complication: Perforation

Perforated marginal ulcers are potentially lethal and may be surgical emergencies. About 1% of all LRYGB patients present with perforated MU.10 Importantly, patients who perforate may present several years following surgery with symptoms that are atypical for most hollow organ perforations.29 Serum inflammation markers may be normal, and signs of free air and peritonitis may not be present on imaging. However, of all patients with perforated MU, 80% had an identifiable risk factor such as smoking history, NSAID use, steroid use, or history of prior MU.10 Although perforation is relatively rare after RYGB, 25% of patients who experience perforation have a recurrence of MU, so this patient population must be carefully followed.30

About two-thirds of MU cases respond to medical treatment alone, but in cases of recalcitrant or complicated ulcers, surgical intervention is necessary.38 Conservative medical treatment involves smoking cessation, NSAID discontinuation, H. pylori eradication, PPIs, and sucralfate.5 Unlike PPI therapy, H2 antagonists have not proven to be effective against MU secondary to the gastrogastric fistula.22 The administration of PPI prophylaxis to prevent MU formation is not standardized in the bariatric community. Although some studies have found no protective effect, others have shown that PPI prophylaxis is effective in reducing the risk of MU, particularly if the patient is already taking NSAIDs.82031 A study of 2830 RYGB cases found that postoperative PPI reduced MU risk by half, and a 90-day course has been shown to be more effective than a 30-day course.1532

Untreated ulcers can lead to strictures and gastric outlet obstruction, so repeat endoscopies to determine healing are critical. Furthermore, endoscopy has emerged as a less invasive option to treat medically refractory marginal ulcers.  Balloon dilatation of strictures caused by marginal ulcers are more safely performed after the ulcers have healed.  If there is severe stenosis that fails 3 attempts at dilatation and/or significant ulceration, a covered stent could be used to treat the stricture.3334 These techniques range from simple interventions, such as removing sutures from the site of a non-healing ulcer, to more complex procedures, such as placing sutures and stents to treat perforated ulcers.213538

Despite the excellent options for medical treatment, about 17% of MU cases require surgical intervention within 8 years of diagnosis.39 Patients with perforations, dilated pouch, gastrogastric fistula, or no modifiable ulcer risk factors are more likely to require revisional surgery. Of MU patients who require revisional surgery, about 72% have a GG fistula.27 Surgery typically involves excising the ulcer and reconstructing a new GJ anastomosis. The success of surgical interventions is variable depending on the center and the patient population. In one study, 87% of patients remain symptom-free after revisional surgery, while in another study 57% of patients had MU recurrence 1-year after revisional surgery.1527

To avoid complications that require revisional surgery, patients at significant risk for MU following RYGB may consider an alternative form of bariatric surgery, such as laparoscopic sleeve gastrectomy (LSG). This includes patients who smoke or are exposed to significant second-hand smoke, patients dependent on steroids, or patients who rely on pre-operative NSAIDs.15 In the management of MU, patients who have no modifiable risk factors and/or live in remote areas without ready access to a bariatric center may consider revision surgery as a first-line definitive treatment for MU. This limits the risk of an untreated ulcer causing a surgical emergency, such as perforation or massive hemorrhage. 

This case describes a laparoscopic surgical revision of a gastric bypass following the development of a marginal ulcer with a gastrogastric fistula. It includes a partial gastrectomy and revision of the gastrojejunostomy to excise the ulcer, vagotomy, and rerouting of the roux limb to the retrocolic retrogastric location. 

The development and subsequent management of MU following RYGB merits several technical considerations. First, gastric pouch size and separation from the remnant affect MU risk. Larger, more distal pouches (such as in biliopancreatic diversions) have a higher risk of MU, whereas a smaller pouch (5-6cm) significantly reduces the risk of MU.84041 In some RYGB cases, the pouch and the gastric remnant are partitioned by a staple line, but not transected and separated. Complete transection, or even removal of the gastric remnant, significantly reduce the risk of GGF and subsequent MU.722

Second, absorbable sutures should be used for the GJ anastomosis to prevent mucosal erosion caused by permanent sutures. On endoscopy, foreign materials such as sutures or staples are found in one-third of marginal ulcers.8 In one study, the incidence of gastrogastric fistulas decreased from 5.1% to 0% when the anastomosis was created with absorbable sutures rather than staples.22 

Third, truncal vagotomy is often performed to reduce acid production by eliminating acetylcholine stimulation on parietal cells. Historically used to treat peptic ulcer disease, truncal vagotomy may also decrease parietal cell sensitivity to gastrin and histamine, and reduce gastrin production from the antrum.42 Recent advances in robotic or minimally-invasive thoracoscopic vagotomy may be useful to treat recalcitrant marginal ulcers.4344 Patients who undergo vagotomy should be monitored for the postvagotomy syndrome, causing diarrhea or gastroparesis.45-47 Patients who undergo vagotomy must remain on PPI for at least three months postop to allow time for the parietal cells to regress. 

Finally, some surgeons prefer to place the roux limb in the retrocolic position to reduce tension on the mesentery and avoid anastomotic ischemia. There is no data to suggest that the positioning of the roux limb affects MU risk, so the decision of whether to use antecolic or retrocolic placement depends on the individual surgeon. 

Early vs. Late

The time of MU onset is an important consideration in identifying the underlying etiology. Early (<30 day post-op) ulcers are rare, occurring in less than 1% of RYGB patients.48 Because these ulcers develop even when absorbable sutures are used, and because they develop before pouch dilation may increase the number of parietal cells, it is unlikely that foreign bodies or acid production are the cause.7 A more plausible explanation is that MU occurring less than a month following surgery is likely the result of inflammation, ischemia, electrocautery, and general tissue damage associated with the surgery.748 Patients who underwent anticoagulation therapy prior to surgery were also much more likely to be diagnosed with an early MU.48 The majority of MU occur later, due to gastrogastric fistulae, pouch dilation, and foreign bodies. Ulcers caused by pouch dilation are typically more aggressive and may present with perforation or severe bleeding. 7 Later MU are also more likely to be related to modifiable risk factors, such as smoking or NSAID use.1249

Improvements in surgical techniques and less-invasive management will greatly improve MU outcomes in the future. During the initial gastric bypass, determining adequate blood flow to the Roux limb is critical to preventing ischemia – a major cause of marginal ulcers. Advancements in fluorescence-based intraoperative angiography can provide real-time information on Roux limb perfusion, allowing surgeons to better visualize anatomy and plan their operative course.5051 The fluorescent molecule indocyanine green (ICG) is a useful tool, as it binds to plasma lipoproteins and is cleared by the liver in a first-pass effect.52 It has been used in LSG, and a recent case report demonstrates its use in revisional surgery for MU following RYGB.5153

The One-Anastomosis gastric bypass (OAGB) is a recently developed bariatric surgery that creates a longer pouch and better preserves the mesentery, allowing better Roux limb perfusion.54 OAGB produces excellent weight-loss outcomes, and the ulcer rate appears to be less than with standard RYGB, most likely owing to the presence of pancreatic fluid at the gastrojejunal anastomosis buffering the acid from the larger pouch size.5556 Robotic RYGB using the double loop technique also preserves the mesentery and therefore may decrease the risk of marginal ulcers.57 While there is no large study showing decreased risk of ulceration, current studies show only a small number of postoperative ulcers.58

Finally, endoscopy is becoming more widely utilized in the management of MU, not merely in the diagnosis. From basic interventions, like endoscopic removal of foreign bodies, to more advanced procedures such as dilatation, sclerotherapy, suturing or stenting, endoscopy may be a less invasive method to treat ulcers. One study reports suturing of a mucosal advancement flap endoscopically for the treatment of a nonhealing MU.5960

No special equipment was used for this operation. 

Nothing to disclose.

The patient referred to in this video article has given their informed consent to be filmed and is aware that information and images will be published online.

Citations

  1. Schauer PR, Ikramuddin S, Gourash W, Ramanathan R, Luketich J. Outcomes after laparoscopic Roux-en-Y gastric bypass for morbid obesity. Ann Surg. 2000;232(4):515-529. https://doi.org/10.1097/00000658-200010000-00007
  2. Buchwald H, Oien DM. Metabolic/bariatric surgery Worldwide 2008. Obes Surg. 2009;19(12):1605-1611. https://doi.org/10.1007/s11695-009-0014-5
  3. Azagury DE, Abu Dayyeh BK, Greenwalt IT, Thompson CC. Marginal ulceration after Roux-en-Y gastric bypass surgery: characteristics, risk factors, treatment, and outcomes. Endoscopy. 2011;43(11):950-954. https://doi.org/10.1055/s-0030-1256951
  4. MacLean LD, Rhode BM, Nohr C, Katz S, McLean AP. Stomal ulcer after gastric bypass. J Am Coll Surg. 1997;185(1):1-7. https://doi.org/10.1016/s1072-7515(01)00873-0
  5. Printen KJ, Scott D, Mason EE. Stomal ulcers after gastric bypass. Arch Surg. 1980;115(4):525-527. https://doi.org/10.1001/archsurg.1980.01380040147026
  6. Sapala JA, Wood MH, Sapala MA, Flake TM, Jr. Marginal ulcer after gastric bypass: a prospective 3-year study of 173 patients. Obes Surg. 1998;8(5):505-516. https://doi.org/10.1381/096089298765554061
  7. Csendes A, Burgos AM, Altuve J, Bonacic S. Incidence of marginal ulcer 1 month and 1 to 2 years after gastric bypass: a prospective consecutive endoscopic evaluation of 442 patients with morbid obesity. Obes Surg. 2009;19(2):135-138. https://doi.org/10.1007/s11695-008-9588-6
  8. Coblijn UK, Goucham AB, Lagarde SM, Kuiken SD, van Wagensveld BA. Development of ulcer disease after Roux-en-Y gastric bypass, incidence, risk factors, and patient presentation: a systematic review. Obes Surg. 2014;24(2):299-309. https://doi.org/10.1007/s11695-013-1118-5
  9. Chahine E, Kassir R, Dirani M, Joumaa S, Debs T, Chouillard E. Surgical Management of Gastrogastric Fistula After Roux-en-Y Gastric Bypass: 10-Year Experience. Obes Surg. 2018;28(4):939-944. https://doi.org/10.1007/s11695-017-2949-2
  10. Felix EL, Kettelle J, Mobley E, Swartz D. Perforated marginal ulcers after laparoscopic gastric bypass. Surg Endosc. 2008;22(10):2128-2132. https://doi.org/10.1007/s00464-008-9996-7
  11. Pratt JSA. Roux-en-Y Gastric Bypass: Stomal Stenosis. In: Nguyen NT, De Maria EJ, Ikramuddin S, Hutter MM, eds. The SAGES Manual: A Practical Guide to Bariatric Surgery. New York, NY: Springer New York; 2008:211-212. Access: http://endosurgery.od.ua/uploaded/site285_Nguyen_The_SAGES_manual-a_practical_guide_to_bariatric_surgery.pdf
  12. Spaniolas K, Yang J, Crowley S, et al. Association of Long-term Anastomotic Ulceration After Roux-en-Y Gastric Bypass With Tobacco Smoking. JAMA surgery. 2018;153(9):862-864. https://doi.org/10.1001/jamasurg.2018.1616
  13. Dittrich L, Schwenninger MV, Dittrich K, Pratschke J, Aigner F, Raakow J. Marginal ulcers after laparoscopic Roux-en-Y gastric bypass: analysis of the amount of daily and lifetime smoking on postoperative risk. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2020;16(3):389-396. https://doi.org/10.1016/j.soard.2019.11.022
  14. Wilson JA, Romagnuolo J, Byrne TK, Morgan K, Wilson FA. Predictors of endoscopic findings after Roux-en-Y gastric bypass. Am J Gastroenterol. 2006;101(10):2194-2199.  https://doi.org/10.1111/j.1572-0241.2006.00770.x
  15. Di Palma A, Liu B, Maeda A, Anvari M, Jackson T, Okrainec A. Marginal ulceration following Roux-en-Y gastric bypass: risk factors for ulcer development, recurrence, and need for revisional surgery. Surg Endosc. 2020. https://doi.org/10.1007/s00464-020-07650-0
  16. Sverdén E, Mattsson F, Sondén A, et al. Risk Factors for Marginal Ulcer After Gastric Bypass Surgery for Obesity: A Population-based Cohort Study. Ann Surg. 2016;263(4):733-737. https://doi.org/ 10.1097/SLA.0000000000001300
  17. Kang X, Hong D, Anvari M, Tiboni M, Amin N, Gmora S. Is Daily Low-Dose Aspirin Safe to Take Following Laparoscopic Roux-en-Y Gastric Bypass for Obesity Surgery? Obes Surg. 2017;27(5):1261-1265. https://doi.org/10.1007/s11695-016-2462-z
  18. Rasmussen JJ, Fuller W, Ali MR. Marginal ulceration after laparoscopic gastric bypass: an analysis of predisposing factors in 260 patients. Surg Endosc. 2007;21(7):1090-1094. https://doi.org/10.1007/s00464-007-9285-x
  19. El-Hayek K, Timratana P, Shimizu H, Chand B. Marginal ulcer after Roux-en-Y gastric bypass: what have we really learned? Surg Endosc. 2012;26(10):2789-2796. https://doi.org/10.1007/s00464-012-2280-x
  20. Gumbs AA, Duffy AJ, Bell RL. Incidence and management of marginal ulceration after laparoscopic Roux-Y gastric bypass. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2006;2(4):460-463. https://doi.org/10.1016/j.soard.2006.04.233
  21. Lee JK, Van Dam J, Morton JM, Curet M, Banerjee S. Endoscopy is accurate, safe, and effective in the assessment and management of complications following gastric bypass surgery. Am J Gastroenterol. 2009;104(3):575-582; quiz 583. https://doi.org/10.1038/ajg.2008.102
  22. Capella JF, Capella RF. Gastro-gastric fistulas and marginal ulcers in gastric bypass procedures for weight reduction. Obes Surg. 1999;9(1):22-27; discussion 28. https://doi.org/10.1381/096089299765553674
  23. Rawlins L, Rawlins MP, Brown CC, Schumacher DL. Effect of Helicobacter pylori on marginal ulcer and stomal stenosis after Roux-en-Y gastric bypass. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2013;9(5):760-764. https://doi.org/10.1016/j.soard.2012.06.012
  24. Schulman AR, Abougergi MS, Thompson CC. H. Pylori as a predictor of marginal ulceration: A nationwide analysis. Obesity (Silver Spring). 2017;25(3):522-526. https://doi.org/10.1002/oby.21759
  25. Marano BJ, Jr. Endoscopy after Roux-en-Y gastric bypass: a community hospital experience. Obes Surg. 2005;15(3):342-345. https://doi.org/10.1381/0960892053576767
  26. Schreiber H, Ben-Meir A, Sonpal I, Patterson L, Salomone M, Marshall JB. Cigarette smoking, but not the presence of H. pylori, is associated with anastomotic ulcers in Roux-en-Y gastric bypass patients. Surgery for Obesity and Related Diseases. 2005;1(3):257. https://doi.org/10.1007/s00464-014-4022-8
  27. Patel RA, Brolin RE, Gandhi A. Revisional operations for marginal ulcer after Roux-en-Y gastric bypass. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2009;5(3):317-322. https://doi.org/10.1016/j.soard.2008.10.011
  28. Dean K, Scott J, Eichhorn P. Aortoenteric Fistula at the Site of a Marginal Ulcer after Roux-en-Y Gastric Bypass. Am Surg. 2018;84(8):e312-e313. PMID: 30842012.
  29. Pohl D, Schmutz G, Plitzko G, Kröll D, Nett P, Borbély Y. Perforated duodenal ulcers after Roux-Y Gastric Bypass. Am J Emerg Med. 2018;36(8):1525.e1521-1525.e1523. https://doi.org/10.1016/j.ajem.2018.04.057
  30. Altieri MS, Pryor A, Yang J, et al. The natural history of perforated marginal ulcers after gastric bypass surgery. Surg Endosc. 2018;32(3):1215-1222. https://doi.org/10.1007/s00464-017-5794-4
  31. Wennerlund J, Gunnarsson U, Strigård K, Sundbom M. Acid-related complications after laparoscopic Roux-en-Y gastric bypass: risk factors and impact of proton pump inhibitors. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2020;16(5):620-625. https://doi.org/10.1016/j.soard.2020.01.005
  32. Kang X, Zurita-Macias L, Hong D, Cadeddu M, Anvari M, Gmora S. A comparison of 30-day versus 90-day proton pump inhibitor therapy in prevention of marginal ulcers after laparoscopic Roux-en-Y gastric bypass. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2016;12(5):1003-1007. https://doi.org/10.1016/j.soard.2015.11.010
  33. Almby K, Edholm D. Anastomotic Strictures After Roux-en-Y Gastric Bypass: a Cohort Study from the Scandinavian Obesity Surgery Registry. Obes Surg. 2019;29(1):172-177. https://doi.org/10.1007/s11695-018-3500-9
  34. Chang J, Sharma G, Boules M, Brethauer S, Rodriguez J, Kroh MD. Endoscopic stents in the management of anastomotic complications after foregut surgery: new applications and techniques. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2016;12(7):1373-1381. https://doi.org/10.1016/j.soard.2016.02.041
  35. Frezza EE, Herbert H, Ford R, Wachtel MS. Endoscopic suture removal at gastrojejunal anastomosis after Roux-en-Y gastric bypass to prevent marginal ulceration. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery. 2007;3(6):619-622. https://doi.org/10.1016/j.soard.2007.08.019
  36. Barola S, Fayad L, Hill C, et al. Endoscopic Management of Recalcitrant Marginal Ulcers by Covering the Ulcer Bed. Obes Surg. 2018;28(8):2252-2260. https://doi.org/10.1007/s11695-018-3162-7
  37. Liu S, Kim R. Successful closure with endoscopic suturing of a recalcitrant marginal ulcer despite Roux-en-Y gastric bypass reversion. VideoGIE. 2019;4(12):554-555. https://doi.org/10.1016/j.vgie.2019.09.001
  38. Vedantam S, Roberts J. Endoscopic Stents in the Management of Bariatric Complications: Our Algorithm and Outcomes. Obes Surg. 2020;30(3):1150-1158. https://doi.org/10.1007/s11695-019-04284-7
  39. Pyke O, Yang J, Cohn T, et al. Marginal ulcer continues to be a major source of morbidity over time following gastric bypass. Surg Endosc. 2019;33(10):3451-3456. https://doi.org/10.1007/s00464-018-06618-5
  40. Edholm D, Ottosson J, Sundbom M. Importance of pouch size in laparoscopic Roux-en-Y gastric bypass: a cohort study of 14,168 patients. Surg Endosc. 2016;30(5):2011-2015. https://doi.org/10.1007/s00464-015-4432-2
  41. Tansel A, Graham DY. New Insight Into an Effective Treatment of Marginal Ulceration After Roux-en-Y Gastric Bypass. Clin Gastroenterol Hepatol. 2017;15(4):501-503. https://doi.org/10.1016/j.cgh.2016.12.025
  42. Lagoo J, Pappas TN, Perez A. A relic or still relevant: the narrowing role for vagotomy in the treatment of peptic ulcer disease. Am J Surg. 2014;207(1):120-126. https://doi.org/10.1016/j.amjsurg.2013.02.012
  43. Brungardt J, Tracy B, McBride K, Standiford D, Bailey BM. Right Robotic-Assisted Transthoracic Truncal Vagotomy for Marginal Ulcer Disease after Gastric Bypass Surgery. Am Surg. 2018;84(8):e340-e342. PMID: 30842023.
  44. Bonanno A, Tieu B, Dewey E, Husain F. Thoracoscopic truncal vagotomy versus surgical revision of the gastrojejunal anastomosis for recalcitrant marginal ulcers. Surg Endosc. 2019;33(2):607-611. https://doi.org/10.1007/s00464-018-6386-7
  45. Taylor TV, Lambert ME, Torrance HB. Value of bile-acid binding agents in post-vagotomy diarrhoea. Lancet (London, England). 1978;1(8065):635-636. https://doi.org/10.1016/s0140-6736(78)91139-x
  46. Hejazi RA, Patil H, McCallum RW. Dumping syndrome: establishing criteria for diagnosis and identifying new etiologies. Dig Dis Sci. 2010;55(1):117-123. https://doi.org/10.1007/s10620-009-0939-5
  47. Johnston D. Operative mortality and postoperative morbidity of highly selective vagotomy. Br Med J. 1975;4(5996):545-547. https://doi.org/10.1136/bmj.4.5996.545
  48. Clapp B, Hahn J, Dodoo C, Guerra A, de la Rosa E, Tyroch A. Evaluation of the rate of marginal ulcer formation after bariatric surgery using the MBSAQIP database. Surg Endosc. 2019;33(6):1890-1897. https://doi.org/10.1007/s00464-018-6468-6
  49. Bai HX, Lee AM, Rosen MA. Abdominal Pain in a Patient 13 Years After Roux-en-Y Gastric Bypass. Gastroenterology. 2016;150(7):1540-1541. https://doi.org/10.1053/j.gastro.2016.02.081
  50. Gurtner GC, Jones GE, Neligan PC, et al. Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use. Ann Surg Innov Res. 2013;7(1):1. https://doi.org/10.1186/1750-1164-7-1
  51. Ortega CB, Guerron AD, Yoo JS. The Use of Fluorescence Angiography During Laparoscopic Sleeve Gastrectomy. Jsls. 2018;22(2). https://doi.org/10.4293/JSLS.2018.00005
  52. Alander JT, Kaartinen I, Laakso A, et al. A Review of Indocyanine Green Fluorescent Imaging in Surgery. International Journal of Biomedical Imaging. 2012;2012:940585. https://doi.org/10.1155/2012/940585
  53. Pokala B, Hosein S, Krause CM, McBride CL. Indocyanine Green Use for Revisional Bariatric Surgery. Videoscopy. 2019;30(1). https://doi.org/10.1089/vor.2019.0614
  54. Solouki A, Kermansaravi M, Davarpanah Jazi AH, Kabir A, Farsani TM, Pazouki A. One-anastomosis gastric bypass as an alternative procedure of choice in morbidly obese patients. J Res Med Sci. 2018;23:84. https://doi.org/10.4103/jrms.JRMS_386_18
  55. Baksi A, Kamtam DNH, Aggarwal S, Ahuja V, Kashyap L, Shende DR. Should Surveillance Endoscopy Be Routine After One Anastomosis Gastric Bypass to Detect Marginal Ulcers: Initial Outcomes in a Tertiary Referral Centre. Obes Surg. 2020. https://doi.org/10.1007/s11695-020-04864-y
  56. Mari A, Khoury T, Daud G, et al. The yield, effectiveness, and safety of gastroscopy in management of early postbariatric upper gastrointestinal pain. Minerva Chir. 2020;75(3):164-168. https://doi.org/10.23736/S0026-4733.20.08282-6
  57. Rebecchi F, Ugliono E, Palagi S, Genzone A, Toppino M, Morino M. Robotic "Double Loop" Roux-en-Y gastric bypass reduces the risk of postoperative internal hernias: a prospective observational study. Surg Endosc. 2020. https://doi.org/10.1007/s00464-020-07901-0
  58. Moser F, Horgan S. Robotically assisted bariatric surgery. The American Journal of Surgery. 2004;188(4, Supplement 1):38-44. https://doi.org/10.1016/j.amjsurg.2004.08.027
  59. Jirapinyo P, Watson RR, Thompson CC. Use of a novel endoscopic suturing device to treat recalcitrant marginal ulceration (with video). Gastrointest Endosc. 2012;76(2):435-439. https://doi.org/10.1016/j.gie.2012.03.681
  60. Storm AC, Thompson CC. Endoscopic Treatments Following Bariatric Surgery. Gastrointest Endosc Clin N Am. 2017;27(2):233-244. https://doi.org/10.1016/j.giec.2016.12.007